Drug Name
Actos (Pioglitazone)

Drug Uses
Actos is used for treating type 2 diabetes in certain patients. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines.

How to use
Use Actos as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Actos by mouth with or without food.
Continue to take Actos even if you feel well. Do not miss any doses. Taking Actos at the same time each day will help you remember to take it.

Drug Class and Mechanism
Actos is a drug that reduces the amount of glucose (sugar) in the blood. It is in a class of anti-diabetic drugs, called "thiazolidinediones", that are used in the treatment of type II diabetes.

Actos also lowers the level of glucose in the blood by reducing the production and secretion of glucose into the blood by the liver. In addition, Actos may alter the blood concentrations of lipids (fats) in the blood. Specifically, it decreases triglycerides and increases the "good" (HDL) cholesterol.

Missed Dose
Actos is a thiazolidinedione antidiabetic. It lowers blood sugar by making the cells of the body more sensitive to the action of insulin.

Storage
Store this medicine at room temperature between 15-30 degrees C (59-86 degrees F).

Warnings/Precautions
Do NOT use Actos if:

• you are allergic to any ingredient in Actos
• you have moderate to severe heart failure
• you have type 1 diabetes
• you have a history of liver problems, including jaundice (yellowing of the skin or eyes), during therapy with a similar medicine called troglitazone

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Actos . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have diabetic ketoacidosis (a severe problem associated with diabetes)
• if you have a history of liver problems, abnormal liver function tests, heart problems (eg, congestive heart failure), or eye or vision problems
• if you have swelling problems (edema)

Some MEDICINES MAY INTERACT with Actos . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Gemfibrozil, insulin, or oral antidiabetic medicines (eg, glipizide) because the risk of low blood sugar may be increased
• Rifampin because it may decrease Actos 's effectiveness, resulting in high blood sugar
• Anticoagulants (eg, warfarin) because their effectiveness may be decreased or the risk of their side effects may be increased by Actos

Possible Side Effects
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

• Headache; muscle aches; sore throat; weight gain.

Seek medical attention right away if any of these SEVERE side effects occur:

• Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; symptoms of heart failure (eg, shortness of breath; sudden unexplained weight gain; swelling of the hands, ankles, or feet); symptoms of liver problems (eg, dark urine; yellowing of the skin or eyes; unexplained nausea, vomiting, or loss of appetite; stomach pain); symptoms of low blood sugar (eg, anxiety, increased sweating, dizziness or drowsiness, headache, chills, tremors, increased hunger); unusual bone pain; unusual tiredness or weakness.

More Information
If you have any questions about Actos , please talk with your doctor, pharmacist, or other health care provider.
Actos is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.